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KMID : 0374919930140010107
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Inje Medical Journal
1993 Volume.14 No. 1 p.107 ~ p.118
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An Immunohistochemical Study of PCNA, EGF and EGF Receptor in Epithelial Odongenic Tumors
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Abstract
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The purposes of this study were to assess proliferative activities and imunolocalization of proliferating cell nuclear antigen(PCNA), epithelial growth factor(EGF) and its receptro(EGF-r) in odotogenic tumors. 27 cases of ameloblastoma, 4 cases
of
AOT(adenomatoid odontogenic tumor), 5 cases of BEGOT(Benign epithelial odontogenic ghost cell tumor) and 2 cases of PIOC(primary intraosseous odntogenic tumor) were retrived from the Department of Oral Pathology, College of Denistry, Seoul
National
University. The control was tooth follicle. They were processed for labelled Streptabidin biotin methods. The primary antibodies used in this study were antibodies to PCNA, EGF and EGF-r.
@ES Following results were obtained.
@EN 1. In control groups, inner enalmel epithelium, stellate and dental follicle showed positive reaction for PCNA.
2. In ameloblastoma, the peripheral cell of small follicle, basa cell of unixystic type and adjacent cell of granular cell showed strong positive reaction for PCNA.
3. In AOT, duct-like cells showed positive reaction for PCNA
4. In AIOC and BEGOT, the peripheral cell of tumor cluster showed strong positive reaction for PCNA.
5. Ameloblastoma and AOT revealed negative reaction for EGF. EGF-r.
6. Positive reaction of BEGOT and PIOC for EGF and EGF-r explained their malignancy potential.
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KEYWORD
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